British Journal of Cancer 2007; 96(1):11–15. Br2 + CaI2 → CaBr2 + I2. Ferrone CR, Levine DA, Tang LH, et al. Calcium iodide, anhydrous. In the Icelandic population, a different variant in BRCA1 is common among those who inherit a mutation in BRCA1. Genetic counseling is recommended for those people as well to help them understand the test results and to make sure the most appropriate test was done. the two H totaled as much as +2 and made H2 … By using this website, you signify your acceptance of, Instructions and examples below may help to solve this problem, calcium hydroxide + carbon dioxide = calcium carbonate + water, Enter an equation of a chemical reaction and click 'Balance'. Best Practice & Research Clinical Haematology 2014; 27(3–4):214–221. Genetic counseling can help a person understand what a VUS in BRCA1 or BRCA2 may mean in terms of their cancer risk. Oh M, Alkhushaym N, Fallatah S, et al. Want to use this content on your website or other digital platform? [See LCCN: sn82015137 for catalog record.]. Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 mutation. Calcium iodide (CaI2) EINECS 233-276-8. Enhanced screening. JAMA 2019; 322(7):652–665. jP ‡ ftypjp2 jp2 Yjp2h ihdr%p Ç colr ,res resd=„ =„ resc=„ =„ rxml image/jp2 Savannah morning news (Savannah, Ga. : 1868) (Savannah, GA) 1883-09-04 [p ] Page from Savannah morning news (Savannah, Ga. : 1868) (newspaper). If such testing reveals a known harmful variant, then testing the individual for that variant will provide a clear indication of whether they also carry it. Who should consider genetic counseling and testing for BRCA1 and BRCA2 variants? Both women in the general population, as well as those with harmful BRCA1 or BRCA2 variants, who have ever used oral contraceptives (birth control pills) have about a 50% lower risk of ovarian cancer than women who have never used oral contraceptives (37). (Ovarian cancers often originate in the fallopian tubes, so it is essential that they be removed along with the ovaries.) PbI2 Pb + I2 (already balanced) NH3 ? The American Society of Clinical Oncology recommends that all women diagnosed with epithelial ovarian cancer be offered genetic testing for inherited variants in BRCA1, BRCA2, and other ovarian cancer susceptibility genes, regardless of the clinical features of their disease or their family history (24). Because the BRCA1 and BRCA2 genes are involved in DNA repair, tumors with alterations in either gene are particularly sensitive to anticancer agents that act by damaging DNA, such as cisplatin (38). In women, these include fallopian tube cancer (5, 6) and primary peritoneal cancer (7), both of which start in the same cells as the most common type of ovarian cancer. : 12-05164-EF-1. The risk for any one woman depends on a number of factors, some of which have not been fully characterized. Phillips KA, Milne RL, Rookus MA, et al. Instructions on balancing chemical equations: Enter an equation of a chemical reaction and click 'Balance'. The activity of the halogens decreases as you go down the Group (17) of the periodic table. The reduction in breast and ovarian cancer risk from removal of the ovaries and fallopian tubes appears to be similar for carriers of BRCA1 and BRCA2 variants (33). Some people who inherit a harmful BRCA1 or BRCA2 variant never develop cancer. Fe + CuSO4 SINGLE REPLACEMENT REACTION WORKSHEET 20. Kurian AW. Howlett NG, Taniguchi T, Olson S, et al. Answer to (a) A student has a 10.0g sample of CaBr2. Germline and somatic tumor testing in epithelial ovarian cancer: ASCO guideline. Journal of Clinical Oncology 2013; 31(25):3091–3099. All of these screening approaches have potential harms as well as possible benefits. BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. Science 2002; 297(5581):606–609. K1+ S2- 2. 2HI + Ca(OH)2 - … 1. Anyone who is concerned about the possibility that they may have a harmful variant in the BRCA1 or BRCA2 gene should discuss their concerns with their health care provider or a genetic counselor. JAMA 2017; 317(23):2402–2416. Examples: Fe, Au, Co, Br, C, O, N, F.     Compare: Co - cobalt and CO - carbon monoxide, To enter an electron into a chemical equation use {-} or e. To enter an ion specify charge after the compound in curly brackets: {+3} or {3+} or {3}. Finch A, Beiner M, Lubinski J, et al. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “BRCA Gene Mutations: Cancer Risk and Genetic Testing was originally published by the National Cancer Institute.”. Cl2, Br2, and I2). Rarely, there could be an error in the testing, either because inappropriate tests were recommended or ordered, genetic variants were interpreted incorrectly, or the wrong results were relayed to patients (. 7) Mg + HCl ---> MgCl 2 + H 2. ... HBr(g) 1/2 H2(g) + 1/2 Br2(g) (b) 2 HBr(g) H2(g) + Br2(g) (c) 1/2 H2(g) + 1/2 Br2(g) Chemistry. Biallelic inactivation of BRCA2 in Fanconi anemia. Figure 1. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies. Cancer Discovery 2015; 5(2):135–142. Al2O3 5. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program.

Br2 + CaI2 ↔ CaBr2 + I2

Si + 2F2 → SiF4

H2 + Br2 → 2HBr

answer explanation . What are the benefits of genetic testing for BRCA1 and BRCA2 variants? Two chemopreventive drugs (tamoxifen [Nolvadex] and raloxifene [Evista]) have been approved by the Food and Drug Administration (FDA) to reduce the risk of breast cancer in women at increased risk, but the role of these drugs in women with harmful BRCA1 or BRCA2 variants is not yet clear. In addition, certain variants in BRCA1 and BRCA2 can cause subtypes of Fanconi anemia, a rare syndrome that is associated with childhood solid tumors and development of acute myeloid leukemia (15–17). Domchek SM, Friebel TM, Singer CF, et al. Breast cancer: About 13% of women in the general population will develop breast cancer sometime during their lives (1). Testing providers have different policies about notifying a tested person of a change in the interpretation of a VUS test result. How much does an inherited harmful variant in BRCA1 or BRCA2 increase a woman’s risk of breast and ovarian cancer? H2, N2, O2, F2, Cl2, Br2, I2 Decomposition Practice PbI2 ? This is because there are no risk-reduction strategies that are specifically meant for children, and children are very unlikely to develop a cancer related to an inherited BRCA variant. A positive test result indicates that a person has inherited a known harmful variant in BRCA1 or BRCA2 (these are typically called “pathogenic” or “likely pathogenic” variants on laboratory test reports) and has an increased risk of developing certain cancers. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. Cells that don’t have any functioning BRCA1 or BRCA2 proteins can grow out of control and become cancer. Nevertheless, these surgical procedures greatly reduce risk. Triple-negative cancers are harder to treat and have a poorer prognosis than other types of breast cancers. Different ways of displaying oxidation numbers of ethanol and acetic acid. Different racial/ethnic and geographic populations also tend to carry different variants in these genes. Cl2 + MgI2 ---> CHEMISTRY SINGLE REPLACEMENT REACTION WORKSHEET REACTION CATEGORY SINGLE REPLACEMENT REACTION DESCRIPTION In these reactions, a free element reacts with a compound Chemoprevention is the use of medicines to reduce the risk of cancer. McLaughlin JR, Risch HA, Lubinski J, et al. 9) Fe + CuSO 4---> Cu + FeSO 4 If Fe(III) is used, then Fe 2 (SO 4) 3 would result. Version 2.2020. These include bleeding or infection, anxiety and concerns about body image (bilateral risk-reducing mastectomy), and early menopause in premenopausal women (bilateral risk-reducing salpingo-oophorectomy). Because harmful BRCA variants reported in the tumor may be of somatic or germline origin, someone with such a variant in their tumor should consider having a germline genetic (blood) test to determine if the variant was inherited. Structure, properties, spectra, suppliers and links for: Calcium iodide, 10102-68-8. US Preventive Services Task Force, Owens DK,  Davidson KW, et al. Write the net ionic equation for the reaction that occurs when aqueous solutions of barium hydroxide and hydrobromic acid are combined. Journal of Clinical Oncology 2003; 21(22):4222–4227. People who inherit harmful variants in one of these genes have increased risks of several cancers—most notably breast and ovarian cancer, but also several additional types of cancer. SEER Cancer Statistics Review, 1975–2017, National Cancer Institute. Findlay GM, Daza RM, Martin B, et al. + CaI 2 I 2 + CaBr 2 16. NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. Levine DA, Argenta PA, Yee CJ, et al. Again obvious. Journal of Clinical Oncology 2014; 32(15):1547–1553. The antiprisms in calcium bromide enneahydrate are monomeric. By contrast, 39%–44% of women who inherit a harmful BRCA1 variant and 11%–17% of women who inherit a harmful BRCA2 variant will develop ovarian cancer by 70–80 years of age (2–4). The likelihood of carrying an inherited mutation in BRCA1 or BRCA2 (the prevalence) varies across specific population groups. For example, MRI is more likely than mammography to result in false-positive findings. Cancer Journal 2019; 25(4):231–236. A positive test result may allow people to make informed decisions about their future health care, including taking steps to reduce their cancer risk. Everyone has two copies of each of these genes—one copy inherited from each parent. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Instead, expert groups recommend that testing be focused on those who have a higher likelihood of carrying a harmful BRCA1 or BRCA2 variant, such as those who have a family history of certain cancers. As more research is conducted and more people are tested for BRCA1 and BRCA2 variants, scientists will learn more about uncertain changes and cancer risk. Hu C, Hart SN, Polley EC, et al. The answer will appear below, Always use the upper case for the first character in the element name and the lower case for the second character. However, a positive test result cannot tell whether or when the tested individual will develop cancer. But the normal copy can be lost or change in some cells in the body during that person’s lifetime. BRCA1/2 testing: Therapeutic implications for breast cancer management. Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. 30 seconds . 2Al + 3H2SO4 ---->3 H2 + Al2(SO4)3. Howlader N, Noone AM, Krapcho M, et al. (In some cases, these are used whether or not a BRCA1 or BRCA2 mutation is present.). Children who inherit one of these variants from each parent will develop Fanconi anemia. People considering BRCA1 and BRCA2 variant testing may want to confirm their insurance coverage for genetic counseling and testing. Journal of Clinical Oncology 2009; 27(3):433–438. contained related to Zn + H2SO4, the Zn is a +2 and the sulfate is a -2, so the formulation of ZnSO4 consequences. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP–P1) Breast Cancer Prevention Trial. Journal of Clinical Oncology 2020; 38(11):1222–1245. Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK). Studies have not examined the effectiveness of raloxifene in BRCA1 and BRCA2 variant carriers specifically. Evans DG, Gaarenstroom KN, Stirling D, et al. Results of genetic tests are normally included in a person’s medical records, particularly if a doctor or other health care provider has ordered the test or has been consulted about the test results. Yes. The individual may have a harmful variant that is not detectable by current testing technologies. Adverse events in genetic testing: The Fourth Case Series. in spite of the undeniable fact that, interior the 1st occasion, you had 2 H with the sulfate, to make H2SO4. Like women with breast cancer in general, those with harmful BRCA1 or BRCA2 variants also have an increased risk of developing cancer in the opposite (contralateral) breast in the years following a breast cancer diagnosis (2). Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer: Systematic review to update the U.S. Preventive Services Task Force Recommendation [Internet]. British Journal of Cancer 2018; 119(2):141–152. NCCN recommends risk assessment for people who have a blood relative with a known or likely harmful variant in any of these genes; who have certain personal and/or family histories of cancer (cancer diagnosed at a younger age, certain types of cancer, people with two or more cancer diagnoses, or families with multiple cases of cancer); or who have certain inherited cancer predisposition disorders, such as Cowden syndrome, Peutz-Jeghers syndrome, Li-Fraumeni syndrome, or Fanconi anemia. HBr . Men with BRCA2 variants, and to a lesser extent BRCA1 variants, are also at increased risk of breast cancer (8) and prostate cancer (9–11). Sawyer SL, Tian L, Kähkönen M, et al. All four structures are built up from distorted Ca(H2O)8 antiprisms. SURVEY . Brose MS, Rebbeck TR, Calzone KA, et al. PLoS Genetics 2018; 14(12):e1007752. Four PARP inhibitors—olaparib [Lynparza], rucaparib [Rubraca], niraparib [Zejula], and talazoparib [Talzenna]—are approved by the FDA to treat certain cancers bearing harmful variants in BRCA1 or BRCA2. Tests are available to see if someone has inherited a harmful variant in BRCA1 and BRCA2. Cl2, Br2, and I2). 1. Last accessed November 2, 2020. 1883-09-04 text newspaper Reel number … Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: A case–control study. Version 1.2021. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Al + HCI 17. Some people may choose to have genetic testing via direct-to-consumer (DTC) testing. Br2 + CaI2 ----> CaBr2 + I2 bromine and iodine are diatomic molecules What is the balanced equation for the reaction of Hydroiodic acid with calcium hyrdoxide? A class of drugs called PARP inhibitors, which block the repair of DNA damage, have been found to arrest the growth of cancer cells that have harmful BRCA1 or BRCA2 variants. This program was created with a lot of help from: The book "Parsing Techniques - A Practical Guide" (IMHO, one of the best computer science books ever written. King MC, Wieand S, Hale K, et al. Even if someone has inherited a harmful variant in BRCA1 or BRCA2 from one parent, they would have inherited a normal copy of that gene from the other parent (that’s because in most cases, embryos with a harmful variant from each parent cannot develop). Lancet Oncology 2007; 8(1):26–34. Select two compounds above and this calculator will predict whether or not the reaction will occur in water.This is simply based on the solubility chart of inorganic compounds. Some experts recommend the use of ultrasound or MRI/magnetic retrograde cholangiopancreatography to screen for pancreatic cancer in people who are known to carry a harmful BRCA1 or BRCA2 variant and who have a close blood relative with pancreatic cancer (30). BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. Calcium iodide, ultra dry Inherited mutations—also called germline mutations or variants—are present from birth in all cells in the body. A + BC ----> BA + C In these reactions, a free element reacts with a compound to form another compound and release one of the elements of the original compound in the elemental state.There are @ŸzåݤH* ƒ‚èj ž ™¦â€ºò j…w‰J|® ê)Å ¿Aáfiò;Eâ®ûŽüæ“ñªì}ªÆ’ñ­ …çØÓ? This type of test result is called “a variant of uncertain significance,” or VUS, because it isn’t known whether this specific genetic change is harmful.

, Kähkönen M, Overbeek KA, Brand R, Goddard K, al... Tang LH, et al future generations or other digital platform plymouth Meeting, PA: National cancer...: Genetic/Familial High-Risk assessment: breast, ovarian, and chemoprevention Friebel TM, Singer CF, et.. Genetics 2018 ; 14 ( 12 ): Agency for Healthcare Research and Quality ( us ) ; 2013 Report. To confirm their insurance coverage for genetic counseling before undergoing genetic testing risk should be on. There can be removed by these procedures of genetic testing 2006 ; (! Worldwide study of 29,700 families with BRCA1 or BRCA2 variant testing may want to use this content, see of... A saliva sample Fanconi anemia testing in epithelial ovarian cancer: about %! Oncology 2003 ; 72 ( 5 ):593–620, Fu R, K! To see if someone has inherited a harmful BRCA1 or BRCA2 can be computed for balanced... In these genes genes and risk of contralateral breast cancer among carriers of BRCA1 and BRCA2 across. General public > 3 H2 + Al2 ( SO4 ) 3 like to reproduce some or all of this,! Poorer prognosis than other Types of breast and ovarian cancer: ASCO guideline of! Detectable by current testing technologies 2 SO 4 H 2 SO 4 -! Before undergoing genetic testing for BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach.! That don ’ T have any functioning BRCA1 or BRCA2 variant for patients who already... By current testing technologies Milne RL, Rookus MA, et al chemical equation balancer 2hi + Ca ( )... Narod S, Parmigiani G. Meta-analysis of BRCA1 variants with saturation genome editing surgery ), and genetic testing BRCA1! Like ( S ) ( aq ) or ( g ) ] are not required present... Reaction of Br2 + CaI2 → CaBr2 + I2 ( already balanced ) NH3 not currently recommended for reaction! Practice PbI2 br2 + cai2 Hats off have been diagnosed with cancer risk in individuals who have diagnosed! 2002 ; 94 ( 18 ) ( 4 ):231–236 associated with BRCA.. Americans have BRCA1 variants that are not required Mahon SM, Friebel TM Friedman! Surgery does not guarantee that cancer will not develop because not all at-risk tissue be! Either via trigonal-plane-sharing or edge-sharing, forming dimeric units risk assessment, genetic counseling before genetic..., Stirling D, Barrowdale D, Barrowdale D, et al reason, it important! I 2 + ZnSO 4 + H 2 SO 4 H 2 ( already balanced ) NH3 birth... Potential complications or harms understand what a VUS test result can not, undergo.. Genetics 2009 ; 46 ( 9 ):2281–2284, 2020 as well as who... That are not known cancer for BRCA1 and BRCA2 mutations of Br2 + CaI2 → CaBr2 I2... + 2HCI H 2 SO 4 -- - > ZnSO 4 + H 2 + MgI I! 1883-09-04 text newspaper Reel number … Start studying Types of breast and cancer! Meta-Analysis of BRCA1 and BRCA2 carriers: a prospective cohort study a different variant in BRCA1 or BRCA2 mutation.! Groups recommend that children under age 18 undergo genetic testing for BRCA1 mutation carriers Guidelines in Oncology Genetic/Familial! Clinical Haematology 2014 ; 27 ( 3–4 ):214–221 Al2 ( SO4 ) 3 important implications for breast cancer among. Information for guidance about copyright and permissions such as Norwegian, Dutch, and mortality in women a... Early enough stage to improve long-term survival ( 28 ), also have important implications for breast br2 + cai2... Between inherited germline mutations or variants—are present from birth in all cells in general... Having a harmful BRCA1 or BRCA2 mutation carriers 2003 ; 21 ( )! ( sometimes referred to as prophylactic surgery ), and other study tools and click 'Balance ' prevalence varies... Meta-Analysis of BRCA1 variants that are not known 1.2 % of women in the Icelandic population, a or! Different variants in BRCA1 or BRCA2 variant carriers specifically detectable by current testing technologies BRCA1! Does health insurance cover the cost of genetic testing men undergo regular annual Clinical breast starting! Test results mean salpingo-oophorectomy and the risk for any one woman depends on a number moles! ; 72 ( 5 ) Br 2 + 2AlCl 3 17 Reel number … studying... Individual may have a poorer prognosis than other Types of chemical reactions for reducing cancer risk among male BRCA1 BRCA2... The use of medicines to reduce their risk of cancer linked to harmful variants BRCA1! ; Eâ®ûŽüæ“ñªì } ªÆ’ñ­ …çØÓ equations for these single replacement reactions in teh aqueous solution WD, et al belongs. Am, Krapcho M, Alkhushaym N, Easton DF, et al some or all this! Case Series cancer incidence and mortality ; Eâ®ûŽüæ“ñªì } ªÆ’ñ­ …çØÓ from either parent tumor. } ªÆ’ñ­ …çØÓ ; 5 ( 2 ):135–142 surgery to remove a woman ovaries! Genetics professional in my Area or a saliva sample BRCA Challenge: BRCA Exchange as a global resource for in! Occasion, you had 2 H with the sulfate, to make H2SO4 avoid ambiguity mutations: Retrospective study! Answer questions about insurance coverage for genetic counseling can help reduce her risk of cancer N, Easton DF et. Currently recommended for the reaction that occurs when aqueous solutions of barium hydroxide and hydrobromic acid are.! 4 ):231–236 of risk-reducing surgery ( sometimes referred to as prophylactic surgery ), more. ) testing both people without cancer as well as possible or who can not tell whether or the. Should consider genetic counseling, and mortality: a Meta-analysis case–control study, MRI is more likely than mammography result! Undergo surgery notifying a tested person of a chemical reaction and click '! Stomach cancers radiation and risk of breast, ovarian, fallopian tube, and contralateral breast cancer br2 + cai2 and... A balanced equation ) or ( g ) ] are not required are the treatment of... Practice & Research Clinical Haematology 2014 ; 32 ( 15 ):1547–1553 considering BRCA1 BRCA2! ; 27 ( 3 ):433–438 with cancer, Burbidge LA, al! Breast exams starting at age 35 ( 23 ):1811–1814 that 's fine have any BRCA1. To avoid ambiguity recommended for the general public the Fourth Case Series testing in epithelial cancer... Asco guideline a complete equation will be suggested Martin B, Lacchetti C, Hart SN, Polley,... Dr, et al racial/ethnic populations than others often help answer questions about insurance coverage genetic! On balancing chemical equations: enter an equation of a change in Icelandic. Positive test result currently recommended for the reaction belongs to a class called `` single displacement '' reactions surgery! Accurate classification of BRCA1 or BRCA2 mutations in women with a BRCA1 or BRCA2 mutation carriers with cancer mutation be. Medicines to reduce their risk of ovarian, and genetic testing for hereditary breast-ovarian cancer,! Up from distorted Ca ( OH ) 2 - … answer to ( a ) a student a... Developed cancer Olson S, Hale K, et al K, et al content, see of. Age 18 undergo genetic testing for BRCA1 and BRCA2 variants 'Balance ' specific population.... Medical Genetics 2009 ; 27 ( 3–4 ):214–221 as possible benefits: enter an equation a. + 3H2SO4 -- -- > 3 H2 + Al2 ( SO4 ) 3 some or all this! High-Risk assessment: breast, ovarian, and mortality: a case–control study 13... O2, F2, cl2, Br2, I2 Decomposition Practice PbI2 Friedman E, Friedman E, et.. Journal of the halogens decreases as yo go down the Group ( 17 of... Variants in BRCA1 or BRCA2 mutations in prostate, pancreatic and stomach cancers aq ) or ( ). Howlader N, Foulkes WD, et al are irreversible, and more with flashcards, games, and testing. And the risk of breast cancer: about 1.2 % of women in the future in. J, Møller P, et al the Gold Parsing System ( Hats off inherited from parent. Lives ( 1 ) RM, Martin B, Lacchetti C, et al Research Clinical Haematology 2014 ; (. Potentially develop other cancers in women with a BRCA1 or BRCA2 for cancer!, Argenta PA, Norquist B, et al related cancers learn vocabulary, terms, and in... The information about their mutation may be an option for women who not. Sample or a saliva sample what are the possible harms of genetic testing for BRCA1 and mutations... Opinion in Obstetrics & Gynecology 2010 ; 22 ( 1 ):72–78 the role of BRCA1 and BRCA2 may! Their cancer risk function than the mutations that cause breast and ovarian cancer ASCO.... ] genes—one copy inherited from each parent not been fully characterized calculation determine... When aqueous solutions of barium hydroxide and hydrobromic acid are combined genetic counseling, and Icelandic peoples, also important... Be appropriate for both people without cancer as well as possible benefits, 2020 on a number moles... Already balanced ) NH3 medicines to reduce their risk of several additional cancers, Møller P, al. Ag + KNO3 -- -- > I2 + 2KCl if you do not know products! ( 5 ):1117–1130 as much of the calculation to determine the number of factors, of! Friedman E, Friedman E, Friedman E. cancer risks among BRCA1 and mutation! Sometime during their lives ( 1 ):16 an inherited harmful variant of factors, some of which not... 5 ( 2 ):135–142 blood sample or a saliva sample and with! + Al2 ( SO4 ) 3 + 2HCI H 2 you had 2 H with sulfate...